Sertraline (trade names Zoloft and others) is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It was a very bad way to find out you're Bipolar and even worse that the medication you take is causing you to be worse. It had worked for me for about 12 years, with no weight gain, nor sexual side effects. I was one of those that could not take Celexa, i took mine at night and was so drunk in mornings i couldn't walk. I was on celexa for only a short period of time. Not more than seven months or so. Most of the other members answered your question well, so nothing to add. I'm currently almost 8 weeks pregnant and have made the decision that the risks of me coming off Effexor XR are just too high. I'm only on 75mg xr so it's a pretty low dose and I've done a lot of research everywhere about risks vs benefits. I ended up on it because of two miscarriages and a bunch of other stuff that triggered a pretty catastrophic personal meltdown.